Pyrrothiogatain

Chemical Structure : Pyrrothiogatain

CAS No.: 477888-48-5

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货号: PC-23949Not For Human Use, Lab Use Only.

Pyrrothiogatain is a small molecule inhibitor of transcription factor GATA3 with IC50 of 54.7 uM, inhibits the DNA-binding activity of GATA3 and other members of the GATA family.

规格	价格	库存
10 mg	￥380	In stock
25 mg	￥580	In stock
50 mg	￥880	In stock
100 mg		Get quote

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生物&药学活性

Pyrrothiogatain is a small molecule inhibitor of transcription factor GATA3 with IC50 of 54.7 uM, inhibits the DNA-binding activity of GATA3 and other members of the GATA family.
Pyrrothiogatain also inhibited the interaction between GATA3 and SOX4, suggesting that it interacts with the DNA-binding region of GATA3.
Pyrrothiogatain significantly suppressed Th2 cell differentiation, without impairing Th1 cell differentiation, and inhibited the expression and production of Th2 cytokines.
Pyrrothiogatain inhibited GATA3 DNA-binding to Th2 cytokine gene locus.

物理化学性质&存储条件

分子量	221.27
分子式	C11H11NO2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2,5-Dimethyl-1H-pyrrol-1-yl)thiophene-2-carboxylic acid

参考文献

1. Nomura S, et al. Sci Rep. 2019 Nov 22;9(1):17335.