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首页-小分子抑制剂&激动剂-Others-Other Targets-Pyrimidinone 8
Pyrimidinone 8

Chemical Structure : Pyrimidinone 8

CAS No.: 65004-42-4

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Pyrimidinone 8

货号: PC-61214Not For Human Use, Lab Use Only.

Pyrimidinone 8 is a novel allosteric, non-competitive divalent metal transporter-1 (SLC11A2/DMT1) inhibitor with Ki of 20 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Pyrimidinone 8 is a novel allosteric, non-competitive divalent metal transporter-1 (SLC11A2/DMT1) inhibitor with Ki of 20 uM.
    Pyrimidinone 8 does not affect hDMT1 cell surface expression and shows no dependence on extracellular pH.

    物理化学性质&存储条件

    分子量 204.233
    分子式 C10H12N4O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one

    参考文献

    1. Montalbetti N, et al. Biochem Pharmacol. 2015 Aug 1;96(3):216-24.

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