Pyridostatin | G-quadruplex stabilizer | Probechem Biochemicals

Chemical Structure : Pyridostatin

CAS No.: 1085412-37-8

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Pyridostatin (RR82)

货号: PC-73357Not For Human Use, Lab Use Only.

Pyridostatin (RR82) is a high-affinity G-quadruplex-stabilizing small molecule (Kd=490 nM), promotes the folding of telomeric G-quadruplexes, induces DNA damage and cell cycle arrest.

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25 mg	￥1480	In stock
100 mg	￥4280	In stock
200 mg	￥7280	In stock
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生物&药学活性

Pyridostatin (RR82) is a high-affinity G-quadruplex-stabilizing small molecule (Kd=490 nM), promotes the folding of telomeric G-quadruplexes, induces DNA damage and cell cycle arrest.
Pyridostatin targets the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells.
Pyridostatin also targets telomeric G-quadruplexes, inducing telomerase dysfunction.
Pyridostatin activates the DNA-dependent protein kinase catalytic sunbunit (DNA-PKcs).
Pyridostatin decreases the Epstein-Barr virus-encoded nuclear antigen 1 (EBNA1) synthesis.

物理化学性质&存储条件

分子量	596.6
分子式	C31H32N8O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-Aminoethoxy)-N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)pyridine-2,6-dicarboxamide

参考文献

1. Koirala D, et al. Nat Chem. 2011 Aug 28;3(10):782-7.

2. McLuckie KI, et al. J Am Chem Soc. 2013 Jul 3;135(26):9640-3.

3. Rodriguez R, et al. Nat Chem Biol. 2012 Feb 5;8(3):301-10.

4. Murat P, et al. Nat Chem Biol. 2014 May;10(5):358-64.

Pyridostatin (RR82)

生物&药学活性

物理化学性质&存储条件

参考文献

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Pyridostatin (RR82)

生物&药学活性

物理化学性质&存储条件

参考文献

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