Pyr6 | TRPC3 inhibitor| Probechem Biochemicals

Chemical Structure : Pyr6

CAS No.: 245747-08-4

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Pyr6 (TRPC3 inhibitor Pyr6)

货号: PC-43073Not For Human Use, Lab Use Only.

Pyr6 is a potent, selective inhibitor of TRPC3 channel with IC50 of 0.49 uM (thapsigargin-depleted native RBL-2H3 cells for SOCE).

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5 mg	￥880	In stock
10 mg	￥1380	In stock
25 mg	￥2380	In stock
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100 mg		Get quote

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生物&药学活性

Pyr6 is a potent, selective inhibitor of TRPC3 channel with IC50 of 0.49 uM (thapsigargin-depleted native RBL-2H3 cells for SOCE).
Pyr6 exhibits a 37-fold higher potency to inhibit Orai1-mediated Ca(2+) entry as compared with TRPC3-mediated Ca(2+) entry.
Pyr6 inhibits Orai1- and TRPC3-mediated Ca(2+) entry and currents, potently suppresses mast cell activation.

物理化学性质&存储条件

分子量	418.2684
分子式	C17H9F7N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Pyridinecarboxamide, N-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-

参考文献

1. Schleifer H, et al. Br J Pharmacol. 2012 Dec;167(8):1712-22.

2. Dragoni S, et al. Biomed Res Int. 2014;2014:739494.

3. Chauvet S, et al. Front Pharmacol. 2016 Dec 12;7:486.

Pyr6 (TRPC3 inhibitor Pyr6)

生物&药学活性

物理化学性质&存储条件

参考文献

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Pyr6 (TRPC3 inhibitor Pyr6)

生物&药学活性

物理化学性质&存储条件

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