Pyr3

Chemical Structure : Pyr3

CAS No.: 1160514-60-2

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货号: PC-23550Not For Human Use, Lab Use Only.

Pyr3 is a potent, selective inhibitor of transient receptor potential canonical channel 3 (TRPC3) with IC50 of 700 nM for inhibition of TRPC3-mediated Ca2+ influx.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3480	In stock
100 mg		Get quote

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生物&药学活性

Pyr3 is a potent, selective inhibitor of transient receptor potential canonical channel 3 (TRPC3) with IC50 of 700 nM for inhibition of TRPC3-mediated Ca2+ influx.
Pyr3 shows no effect on Ca2+ influx mediated by other TRPC members, Ca2+ responses in the absence of extracellular Ca2+, and the control basal [Ca2+]i levels.
Pyr3 potently eliminates the Ca2+ influx-dependent PLC translocation to the plasma membrane and late oscillatory phase of B cell receptor-induced Ca2+ response in DT40 B lymphocytes.
Pyr3 attenuates activation of nuclear factor of activated T cells, a Ca2+-dependent transcription factor, and hypertrophic growth in rat neonatal cardiomyocytes, and in vivo pressure overload-induced cardiac hypertrophy in mice.

物理化学性质&存储条件

分子量	456.63
分子式	C16H11Cl3F3N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ethyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

参考文献

1. Kiyonaka S, et al. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5400-5.

Pyr3

生物&药学活性

物理化学性质&存储条件

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Pyr3

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