Purpurin

Chemical Structure : Purpurin

CAS No.: 81-54-9

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货号: PC-23556Not For Human Use, Lab Use Only.

Purpurin is a potent, specific inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1) with Ki of 1.9 uM, inhibits cancer cell proliferation and tumor growth.

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100 mg	￥480	In stock
250 mg	￥780	In stock
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生物&药学活性

Purpurin is a potent, specific inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1) with Ki of 1.9 uM, inhibits cancer cell proliferation and tumor growth.
Purpurin specifically inhibits activity of GDH but not other NADPH-dependent enzymes such as 6-phosphogluconate dehydrogenase (6PGD) and fumarate hydratase (FH) in vitro.
Purpurin exerts dose-dependently antidepressant-like effects on behavior and stress axis reactivity in adult male C57BL/6J mice.

物理化学性质&存储条件

分子量	256.21
分子式	C14H8O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1,2,4-Trihydroxyanthracene-9,10-dione

参考文献

1. Jin L, et al. Cancer Cell. 2015 Feb 9;27(2):257-70.

2. Ma L, et al. Psychopharmacology (Berl). 2020 Mar;237(3):887-899.

Purpurin

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Purpurin

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