Pulrodemstat (CC-90011) is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with biochemical IC50 of 0.3 nM.
Pulrodemstat (CC90011) is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with biochemical IC50 of 0.3 nM.
CC-90011 inhibits gastrin-releasing peptide (GRP) mRNA expression in H209 and H1417 cell lines with IC50 of 3 nM and 4 nM, respectively.
CC-90011 exhibits potent antiproliferative activity (EC50=6 nM, H1417) that correlated with GRP suppression.
CC-90011 exhibits potent on-target induction of cellular differentiation in acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cell lines, and antitumor efficacy in patient-derived xenograft (PDX) SCLC models.
