Psora-4 |CAS:724709-68-6 Probechem Biochemicals

Chemical Structure : Psora-4

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Psora-4 (Psora4)

货号: PC-62203Not For Human Use, Lab Use Only.

Psora-4 is a potent and selective Kv1.3 potassium channel blocker with EC50 of 3 nM.

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生物&药学活性

Psora-4 is a potent and selective Kv1.3 potassium channel blocker with EC50 of 3 nM.
Psora-4 shows 17- to 70-fold selectivity for Kv1.3 over closely related Kv1-family channels (Kv1.1, Kv1.2, Kv1.4, and Kv1.7) with the exception of Kv1.5 (EC50, 7.7 nM), and shows no effect on hERG, Kv3.1, the calcium-activated K+ channels (IKCa1, SK1-SK3, and BKCa), or the neuronal NaV1.2 channel.
Psora-4 selectively suppresses the proliferation of human and rat myelin-specific effector memory T cells with EC50 of 25 and 60 nM, respectively, without persistently suppressing peripheral blood naive and central memory T cells.

物理化学性质&存储条件

分子量	334.371
分子式	C21H18O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-Phenylbutoxy)-7H-furo[3,2-g][1]benzopyran-7-one

参考文献

1. Vennekamp J, et al. Mol Pharmacol. 2004 Jun;65(6):1364-74.

2. Wulff H, et al. Nat Chem Biol. 2013 Aug;9(8):473-4.

3. Schmitz A, et al. Mol Pharmacol. 2005 Nov;68(5):1254-70.

Psora-4 (Psora4)

生物&药学活性

物理化学性质&存储条件

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Psora-4 (Psora4)

生物&药学活性

物理化学性质&存储条件

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