Prucalopride | 5-HT4 agonist | Probechem Biochemicals

Chemical Structure : Prucalopride

CAS No.: 179474-81-8

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Prucalopride (R-108512, R108512)

货号: PC-23280Not For Human Use, Lab Use Only.

Prucalopride (R-108512) is a potent, selective 5-HT4 receptor agonist with pKi of 8.6 and 8.1 for 5-HT4a and 5-HT4b, >290-fold higher affinity for 5-HT4 receptors than for other receptors.

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50 mg	￥880	In stock
100 mg	￥1380	In stock
250 mg	￥2180	In stock
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生物&药学活性

Prucalopride (R-108512) is a potent, selective 5-HT4 receptor agonist with pKi of 8.6 and 8.1 for 5-HT4a and 5-HT4b, >290-fold higher affinity for 5-HT4 receptors than for other receptors.
Prucalopride targets the impaired motility associated with chronic constipation, thus normalizing bowel movements.
Prucalopride induces contractions (pEC50=7.48) in the guinea-pig colon, demonstrates anti-cholinergic, anticholinesterase or nonspecific inhibitory activity and does not antagonise 5-HT2A, 5-HT2B and 5-HT3 receptors or motilin, CCK1 receptors.

物理化学性质&存储条件

分子量	367.87
分子式	C18H26ClN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide

参考文献

1. Prins NH, et al. Br J Pharmacol. 1999 Jul;127(6):1431-7.

2. Poen AC, et al. Aliment Pharmacol Ther. 1999 Nov;13(11):1493-7.

3. Briejer MR, et al. Eur J Pharmacol. 2001 Jun 29;423(1):71-83.

Prucalopride (R-108512, R108512)

生物&药学活性

物理化学性质&存储条件

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Prucalopride (R-108512, R108512)

生物&药学活性

物理化学性质&存储条件

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