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Propofol

Chemical Structure : Propofol

CAS No.: 2078-54-8

Propofol (2,6-Diisopropylphenol)

货号: PC-70280Not For Human Use, Lab Use Only.

Propofol (2,6-Diisopropylphenol) is a widely used general anesthetic to induce and maintain anesthesia, also inhibits kinesin-1 KIF5B and kinesin-2 KIF3AB and KIF3AC.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Propofol (2,6-Diisopropylphenol) is a widely used general anesthetic to induce and maintain anesthesia, also inhibits kinesin-1 KIF5B and kinesin-2 KIF3AB and KIF3AC.
Propofol (2,6-Diisopropylphenol) influences ligand-gated channels, including the GABAA receptor and others.
Propofol (2,6-Diisopropylphenol) also inhibits conventional kinesin-1 KIF5B and kinesin-2 KIF3AB and KIF3AC, causing a significant reduction in the distances that these processive kinesins can travel without an effect on velocity (EC50<100 nM).

物理化学性质&存储条件

分子量 178.271
分子式 C12H18O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Phenol, 2,6-diisopropyl- (6CI,8CI)

参考文献

1. Bensel BM, et al. Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4281-E4287.

2. Jin WZ, et al. Eur J Pharmacol. 2016 Oct 5;788:37-44.

3. Eaton MM, et al. Curr Neuropharmacol. 2016;14(7):772-80.

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