Prodigiosin | Wnt/β-catenin inhibitor | Probechem Biochemicals

Chemical Structure : Prodigiosin

CAS No.: 82-89-3

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Prodigiosin (Prodigiosine, NSC47147)

货号: PC-70223Not For Human Use, Lab Use Only.

Prodigiosin is a natural red pigment produced by numerous bacterial species, has exhibited promising anticancer activity.

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500 ug	￥1880	In stock
1 mg	￥2980	In stock
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10 mg		Get quote

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生物&药学活性

Prodigiosin is a natural red pigment produced by numerous bacterial species, has exhibited promising anticancer activity.
Prodigiosin a potent inhibitor of Wnt/β-catenin pathway by targeting multiple sites of this pathway, including LRP6, Dishevelled (DVL), and GSK3β.
Prodigiosin decreases phosphorylation of LRP6, DVL2, and GSK3β and suppressed β-catenin-stimulated Wnt target gene expression, including expression of cyclin D1, in breast cancer cells.
Prodigiosin slows tumor progression in vivo; restores p53 and activates p73 via regualtion of c-Jun in colorectal cancer stem cells.

物理化学性质&存储条件

分子量	323.432
分子式	C20H25N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Methoxy-5-[(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl]-2,2'-bi-1H-pyrrole

参考文献

1. Wang Z, et al. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13150-13155.

2. Prabhu VV, et al. Cancer Res. 2016 Apr 1;76(7):1989-99.

Prodigiosin (Prodigiosine, NSC47147)

生物&药学活性

物理化学性质&存储条件

参考文献

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Prodigiosin (Prodigiosine, NSC47147)

生物&药学活性

物理化学性质&存储条件

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