Pristimerin

Chemical Structure : Pristimerin

CAS No.: 1258-84-0

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货号: PC-25686Not For Human Use, Lab Use Only.

Pristimerin is a potent and reversible monoacylglycerol lipase (MAGL, MGL) inhibitor with IC50 of 93 nM (purified MGL).

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5 mg	￥580	In stock
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

Pristimerin is a potent and reversible monoacylglycerol lipase (MAGL, MGL) inhibitor with IC50 of 93 nM (purified MGL).
Pristimerin inhibits non-purified MGL (cell lysates of MGL-transfected HeLa cells) with IC50 of 398 nM.
Pristimerin inhibits MGL through a mechanism that is rapid, reversible and non-competitive, shows reversible interaction with Cys208 of MAGL.
Pristimerin protects 2-AG from degradation in intact rat brain neurons.
Pristimerin also potently inhibits 2-AG-hydrolyzing enzyme, ABHD6, with IC50 of 98 nM.

物理化学性质&存储条件

分子量	464.65
分子式	C30H40O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylate

参考文献

1. King AR, et al. Chem Biol. 2009 Oct 30;16(10):1045-52.

Pristimerin

生物&药学活性

物理化学性质&存储条件

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Pristimerin

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