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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Matrix Metalloproteinase (MMP)-Prinomastat
Prinomastat

Chemical Structure : Prinomastat

CAS No.: 192329-42-3

Prinomastat (AG3340, KB-R9896, AG-3340)

货号: PC-62944Not For Human Use, Lab Use Only.

Prinomastat (AG3340) is a potent, selective MMP inhibitor with pM affinities for inhibiting gelatinases (MMP-2 and -9, Ki=50-150 pM), MMP-14 and MMP-13.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Prinomastat (AG3340) is a potent, selective MMP inhibitor with pM affinities for inhibiting gelatinases (MMP-2 and -9, Ki=50-150 pM), MMP-14 and MMP-13.
AG3340 demonstrates broad antitumor activity in a number of tumor models, inhibits glioma invasion or growth of the human malignant glioma cell line U87.
AG3340 also suppresses tumor growth in a malignant glioma tumor model.

物理化学性质&存储条件

分子量 423.502
分子式 C18H21N3O5S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-Thiomorpholinecarboxamide, N-hydroxy-2,2-dimethyl-4-[[4-(4-pyridinyloxy)phenyl]sulfonyl]-, (S)-

参考文献

1. Price A, et al. Clin Cancer Res. 1999 Apr;5(4):845-54.

2. Santos O, et al. Clin Exp Metastasis. 1997 Sep;15(5):499-508.

3. Shalinsky DR, et al. Ann N Y Acad Sci. 1999 Jun 30;878:236-70.

4. Shalinsky DR, et al. Clin Cancer Res. 1999 Jul;5(7):1905-17.

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