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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Checkpoint Kinase (Chk)-Prexasertib
Prexasertib

Chemical Structure : Prexasertib

CAS No.: 1234015-52-1

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Prexasertib (LY-2606368;LY 2606368;LY2606368)

货号: PC-45427Not For Human Use, Lab Use Only.

Prexasertib (LY-2606368) is a potent, selective, ATP-competitive inhibitor of CHK1 with Ki of 0.9 nM.

规格 价格 库存 数量
5 mg ￥1280 In stock
10 mg ￥1880 In stock
25 mg ￥3180 In stock
50 mg ￥5280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Prexasertib (LY-2606368) is a potent, selective, ATP-competitive inhibitor of CHK1 with Ki of 0.9 nM.
Prexasertib (LY-2606368)  potently abrogates the G2-M checkpoint activated by doxorubicin in p53-deficient HeLa cells with EC50 of 9 nM.
Prexasertib (LY-2606368)  causes replication catastrophe in vitro and in vivo.
Prexasertib (LY-2606368)  shows significant tumor growth inhibition in xenograft tumor models.

物理化学性质&存储条件

分子量 365.3892
分子式 C18H19N7O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 60 mg/mL
Chemical Name/SMILES

2-Pyrazinecarbonitrile, 5-[[5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-

参考文献

1. King C, et al. Mol Cancer Ther. 2015 Sep;14(9):2004-13.

2. Lowery CD, et al. Clin Cancer Res. 2017 Aug 1;23(15):4354-4363.

3. Sen T, et al. Cancer Res. 2017 Jul 15;77(14):3870-3884.

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