Prednisolone

Chemical Structure : Prednisolone

CAS No.: 50-24-8

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货号: PC-45281Not For Human Use, Lab Use Only.

Prednisolone is a potent, orally active corticosteroid and a glucocorticoid, shows Ki of 5.4 nM and 0.26 nM for Glucocorticoid receptor (GR) and Mineralocorticoid receptor (MR), produces transactivation at both the GR (EC50=24.3 nM) and MR (EC50=11.8 nM), with no detectable transactivation of the PR.

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生物&药学活性

Prednisolone is a potent, orally active corticosteroid and a glucocorticoid, shows Ki of 5.4 nM and 0.26 nM for Glucocorticoid receptor (GR) and Mineralocorticoid receptor (MR), produces transactivation at both the GR (EC50=24.3 nM) and MR (EC50=11.8 nM), with no detectable transactivation of the PR.

物理化学性质&存储条件

分子量	360.444
分子式	C21H28O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11β)-

参考文献

1. Florian Jakob, et al. Front Pharmacol. 2025 Mar 5:16:1542351.

Prednisolone

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Prednisolone

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