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首页-小分子抑制剂&激动剂-GPCR-Dopamine Receptor-Pramipexole dihydrochloride
Pramipexole dihydrochloride

Chemical Structure : Pramipexole dihydrochloride

CAS No.: 104632-25-9

Pramipexole dihydrochloride

货号: PC-45173Not For Human Use, Lab Use Only.

A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively.

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50 mg ¥1280 In stock

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively; also possesses low/insignificant affinity (500–10,000 nM) for the 5-HT1A, 5-HT1B, 5-HT1D, and α2-adrenergic receptors; used for treating Parkinson's disease (PD) and restless legs syndrome (RLS).

Parkinson's Disease

Approved

物理化学性质&存储条件

分子量 284.249
分子式 C10H19Cl2N3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, hydrochloride (1:2), (6S)-

参考文献

1. Newman-Tancredi A, et al. J Pharmacol Exp Ther. 2002 Nov;303(2):805-14.

2. Kvernmo T, et al. Clin Ther. 2006 Aug;28(8):1065-78.

3. Millan MJ, et al. J Pharmacol Exp Ther. 2002 Nov;303(2):791-804.

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