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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Guanylate Cyclase-Praliciguat
Praliciguat

Chemical Structure : Praliciguat

CAS No.: 1628730-49-3

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Praliciguat (IW-1973;IW1973)

货号: PC-60050Not For Human Use, Lab Use Only.

Praliciguat (IW-1973, IW1973) is a potent, orally available soluble guanylate cyclase (sGC) stimulator that concentration-dependently increases the production of cGMP with EC50 of 267 nM.

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10 mg ￥5880 In stock
25 mg ￥8980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Praliciguat (IW-1973, IW1973) is a potent, orally available soluble guanylate cyclase (sGC) stimulator that concentration-dependently increases the production of cGMP with EC50 of 267 nM.
Praliciguat (IW-1973, IW1973)  exhibits renoprotective, anti-inflammatory, and antifibrotic effects in vivo.

物理化学性质&存储条件

分子量 534.37
分子式 C21H14F8N6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,1,1,3,3,3-hexafluoro-2-{[(5-fluoro-2-{1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)-1H-pyrazol-3-yl}pyrimidin-4-yl)amino]methyl}propan-2-ol

参考文献

1. Tobin JV, et al. J Pharmacol Exp Ther. 2018 Apr 11. pii: jpet.117.247429. 

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