PptT inhibitor 8918 |CAS:65009-19-0 Probechem Biochemicals

Chemical Structure : PptT inhibitor 8918

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PptT inhibitor 8918 (Compound 8918)

货号: PC-36063Not For Human Use, Lab Use Only.

PptT inhibitor 8918 (Compound 8918) is a mycobactericidal amidino-urea compound that targets phosphopantetheinyl transferase (PptT, IC50=2.5 uM), shows an MIC90 of 3.1 uM against Mtb H37Rv.

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生物&药学活性

PptT inhibitor 8918 (Compound 8918) is a mycobactericidal amidino-urea compound that targets phosphopantetheinyl transferase (PptT, IC50=2.5 uM), shows an MIC90 of 3.1 uM against Mtb H37Rv.
PptT inhibitor 8918 also exhibits MIC90s ranged from 0.56-3.0 uM (median 1.5 uM) against 29 clinical isolates of Mtb.
PptT inhibitor 8918inhibits growth of WT Mtb, but not of the pptT mutant W170S or WT Mtb expressing the pptT W170S mutant.
PptT inhibitor 8918 kills Mycobacterium tuberculosis (Mtb) by binding and partially inhibiting PptT.

物理化学性质&存储条件

分子量	262.357
分子式	C14H22N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Amidino-urea 1-[(2,6-diethylphenyl)-3-N-ethylcarbamimodoyl]urea

参考文献

1. Ballinger E, et al. Science. 2019 Feb 1;363(6426). pii: eaau8959. doi: 10.1126/science.aau8959.

PptT inhibitor 8918 (Compound 8918)

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物理化学性质&存储条件

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PptT inhibitor 8918 (Compound 8918)

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