Poziotinib (HM781-36B, NOV120101)

Chemical Structure : Poziotinib

CAS No.: 1092364-38-9

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货号: PC-44668Not For Human Use, Lab Use Only.

Poziotinib (HM781-36B, NOV120101) is an irreversible pan-HER inhibitor with IC50 of 3.2/5.3 nM/23.5 nM for EGFRwt/HER-2/HER-4.

规格	价格	库存
5 mg	￥680	In stock
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

Poziotinib (HM781-36B, NOV120101) is an irreversible pan-HER inhibitor with IC50 of 3.2/5.3 nM/23.5 nM for EGFRwt/HER-2/HER-4.
Poziotinib inhibits phosphorylation of HER family and downstream signaling molecules, and induced apoptosis and G1 arrest.
Poziotinib exerts synergistic effects with chemotherapeutic agents.

物理化学性质&存储条件

分子量	491.3423
分子式	C23H21Cl2FN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Propen-1-one, 1-[4-[[4-[(3,4-dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-

参考文献

1. Nam HJ, et al. Cancer Lett. 2011 Mar 28;302(2):155-65.

2. Cha MY, et al. Int J Cancer. 2012 May 15;130(10):2445-54.

3. Kim HJ, et al. Anticancer Drugs. 2012 Mar;23(3):288-97.