Povorcitinib (INCB054707) | JAK1 inhibitor | Probechem Biochemicals

Chemical Structure : Povorcitinib

CAS No.: 1637677-22-5

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Povorcitinib (INCB054707, INCB54707)

货号: PC-73438Not For Human Use, Lab Use Only.

Povorcitinib (INCB054707) is a potent, selective and oral JAK1 inhibitor with IC50 of 8.9 nM, 52-fold selective over JAK2 (IC50=463 nM).

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10 mg	￥3780	In stock
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生物&药学活性

Povorcitinib (INCB054707) is a potent, selective and oral JAK1 inhibitor with IC50 of 8.9 nM, 52-fold selective over JAK2 (IC50=463 nM).
Povorcitinib (INCB054707) reduces IFN signaling and ameliorates cutaneous lesions in systemic lupus erythematosus (SLE).
Povorcitinib (INCB054707) dose-dependently reduced the incidence and severity of cutaneous lesion, abrogated lymphoid tissue and spleen enlargement in a preclinical model of cutaneous lupus erythematosus.

物理化学性质&存储条件

分子量	507.469
分子式	C23H22F5N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-(3-(Cyanomethyl)-3-(3',5'-dimethyl-1H,1'H-[4,4'-bipyrazol]-1-yl)azetidin-1-yl)-2,5-difluoro-N-(1,1,1-trifluoropropan-2-yl)benzamide

参考文献

1. Alavi A, et al. Br J Dermatol. 2022 May;186(5):803-813.
2. Fay B, He X, Margulis A et al. Ann Rheum Dis 2019; 78 (Suppl. 2):221–2.

Povorcitinib (INCB054707, INCB54707)

生物&药学活性

物理化学性质&存储条件

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Povorcitinib (INCB054707, INCB54707)

生物&药学活性

物理化学性质&存储条件

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