Posenacaftor | CFTR corrector | Probechem Biochemicals

Chemical Structure : Posenacaftor

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Posenacaftor (PTI-801, PTI 801)

货号: PC-22022Not For Human Use, Lab Use Only.

Posenacaftor (PTI-801) is a newly developed p.Phe508del-CFTR corrector with EC50 of 0.52 uM (HS-YFP quenching rate).

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生物&药学活性

Posenacaftor (PTI-801) is a newly developed p.Phe508del-CFTR corrector with EC50 of 0.52 uM (HS-YFP quenching rate).
Posenacaftor (PTI-801) at 1 and 3 μM concentrations also demonstrated greater efficacy in rescuing p.Phe508del-CFTR function than VX-661 at 5 μM concentration.
Posenacaftor (PTI-801) rescues p.Phe508del-CFTR processing, PM trafficking, and channel function (upon agonist stimulation) with greater correction effects in combination with ABBV-2222, FDL-169, VX-661, or VX-809, but not with VX-445.
Posenacaftor (PTI-801) exhibits no potentiator activity on low temperature- and corrector-rescued p.Phe508del-CFTR, displays similar behavior to that of VX-445 on genetic revertants.

物理化学性质&存储条件

分子量	445.52
分子式	C27H27NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-Methyl-2-(3-methyl-2-benzofuranyl)-5-[(1R)-1-(tetrahydro-2H-pyran-4-yl)ethoxy]-4-quinolinecarboxylic acid

参考文献

1. Filipa C Ferreira, et al. Eur J Pharmacol. 2024 Mar 15:967:176390.

Posenacaftor (PTI-801, PTI 801)

生物&药学活性

物理化学性质&存储条件

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Posenacaftor (PTI-801, PTI 801)

生物&药学活性

物理化学性质&存储条件

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