Poseltinib | BTK inhibitor | Probechem Biochemicals

Chemical Structure : Poseltinib

CAS No.: 1353552-97-2

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Poseltinib (HM-71224, LY-3337641)

货号: PC-60536Not For Human Use, Lab Use Only.

Poseltinib (HM-71224, LY-3337641) is a potent and selective, covalent inhibitor of Btk with IC50 of 1.95 nM.

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10 mg	￥1880	In stock
25 mg	￥2980	In stock
50 mg	￥4880	In stock
100 mg		Get quote

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生物&药学活性

Poseltinib (HM-71224, LY-3337641) is a potent and selective, covalent inhibitor of Btk with IC50 of 1.95 nM.
Poseltinib also inhibits BMX, TEC, TXK, EGFR in biochemical sense (IC50=0.3-2.5 nM).
Poseltinib effectively inhibits the phosphorylation of Btk and PLCγ2, and inhibits expression of CD40, CD69, and CD86 by activated primary human B cells with IC50 of 4.2, 4.2, and 7.7 nM, respectively.
Poseltinib inhibits the production of TNF-α, IL-6, and IL-1β by human monocytes, and osteoclast formation by human monocytes; ameliorates arthritis in a mouse model.

物理化学性质&存储条件

分子量	470.533
分子式	C26H26N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Propenamide, N-[3-[[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]furo[3,2-d]pyrimidin-4-yl]oxy]phenyl]-

参考文献

1. Park JK, et al. Arthritis Res Ther. 2016 Apr 18;18:91.

2. Akinleye A, et al. J Hematol Oncol. 2013 Aug 19;6:59.

3. Smith PF, et al. Br J Clin Pharmacol. 2017 Jun 21.

Poseltinib (HM-71224, LY-3337641)

生物&药学活性

物理化学性质&存储条件

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Poseltinib (HM-71224, LY-3337641)

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物理化学性质&存储条件

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