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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Aldose Reductase-Ponalrestat
Ponalrestat

Chemical Structure : Ponalrestat

CAS No.: 72702-95-5

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Ponalrestat (ICI 128,436, ICI 128436)

货号: PC-25940Not For Human Use, Lab Use Only.

Ponalrestat (ICI 128436) is a potent, orally active, selective and noncompetitive aldose reductase (AR) inhibitor with Ki of 7 nM (ALR2), inhibits the conversion of glucose to sorbitol.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ponalrestat (ICI 128436) is a potent, orally active, selective and noncompetitive aldose reductase (AR) inhibitor with Ki of 7 nM (ALR2), inhibits the conversion of glucose to sorbitol.

物理化学性质&存储条件

分子量 391.20
分子式 C17H12BrFN2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(3-(4-Bromo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid

参考文献

1. Stribling D, et al. Metabolism. 1985 Apr;34(4):336-44.

2. Ward WH, et al. Biochem Pharmacol. 1990 Jan 15;39(2):337-46.

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