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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-Pomstafori-1
Pomstafori-1

Chemical Structure : Pomstafori-1

CAS No.:

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Pomstafori-1

货号: PC-24235Not For Human Use, Lab Use Only.

Pomstafori-1 is the cell-permeable prodrug of Stafori-1, inhibits STAT4 Tyr693 phosphorylation in NK-92 cell with IC50 of 3.3 uM, selectively inhibits STAT4 activation and IFN-γ induction in cultured human cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Pomstafori-1 is the cell-permeable prodrug of Stafori-1, inhibits STAT4 Tyr693 phosphorylation in NK-92 cell with IC50 of 3.3 uM, selectively inhibits STAT4 activation and IFN-γ induction in cultured human cells.
Pomstafori-1(25 uM) inhibits IL-12/IL-18-mediated STAT4 phosphorylation and IFN-γ induction in NK-92 cells
Pomstafori-1weakly inhibits phosphorylation of STAT3 in HCC-827 cells (IC50 = 19 µM), and STAT5a/5b-phosphorylation in K562 cells to alesser extent still (IC50 > 25 µM).

物理化学性质&存储条件

分子量 550.53
分子式 C24H30F3O7PS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(((difluoro(2-fluoro-4-(5-methylthiophen-3-yl)phenyl)methyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)

参考文献

1. Angew Chem Int Ed Engl. 2025 Mar 11:e202504420.

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