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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-Pomstafib-2
Pomstafib-2

Chemical Structure : Pomstafib-2

CAS No.: 2332841-83-3

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Pomstafib-2 (Pomstafib 2)

货号: PC-61169Not For Human Use, Lab Use Only.

Pomstafib-2 is the pivaloyloxymethyl ester prodrug of Stafib-2, which is a potent, selective STAT5b inhibitor with Ki of 9 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Pomstafib-2 is the pivaloyloxymethyl ester prodrug of Stafib-2, which is a potent, selective STAT5b inhibitor with Ki of 9 nM.
    Pomstafib-2 decreases the phosphorylation at STAT5b Tyr699 with IC50 of 1.5 uM in STAT5b-GFP-transfected K562 cells in human leukaemia cells and induces apoptosis in a STAT5-dependent manner.
    Pomstafib-2 shows high selectivity for STAT5b over STAT5a.

    物理化学性质&存储条件

    分子量 1101.042
    分子式 C52H66N2O20P2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ((((4-((2-(4-((4-phenoxyphenyl)carbamoyl)phenoxy)acetamido)methyl)-1,2-phenylene)bis(oxy))bis(oxo-l5-phosphanetriyl))tetrakis(oxy))tetrakis(methylene) tetrakis(2,2-dimethylpropanoate)

    参考文献

    1. Elumalai N, et al. Sci Rep. 2017 Apr 11;7(1):819.

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