Pomstafib-1 | STAT5b inhibitor | Probechem Biochemicals

Chemical Structure : Pomstafib-1

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Pomstafib-1 (Pomstafib 1)

货号: PC-61168Not For Human Use, Lab Use Only.

Pomstafib-1 is the cell-permeable, pivaloyloxymethylester of Stafib-1, which is a potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 44 nM, >50-fold selectivity over STAT5a.

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生物&药学活性

Pomstafib-1 is the cell-permeable, pivaloyloxymethylester of Stafib-1, which is a potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 44 nM, >50-fold selectivity over STAT5a.
Pomstafib-1 inhibits tyrosine phosphorylation of a STAT5b-GFP fusion protein with high selectivity over the corresponding STAT5a-GFP fusion protein in human leukemia cells.
Pomstafib-1 is a valuable tool for dissecting the functions of STAT5b and STAT5a in mammalian cells.

物理化学性质&存储条件

分子量	1059.005
分子式	C50H64N2O19P2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((((4-((2-((6-(phenylcarbamoyl)naphthalen-2-yl)oxy)acetamido)methyl)-1,2-phenylene)bis(oxy))bis(oxo-l5-phosphanetriyl))tetrakis(oxy))tetrakis(methylene) tetrakis(2,2-dimethylpropanoate)

参考文献

1. Elumalai N, et al. Angew Chem Int Ed Engl. 2015 Apr 13;54(16):4758-63.

2. Elumalai N, et al. Bioorg Med Chem. 2017 Jul 15;25(14):3871-3882.

Pomstafib-1 (Pomstafib 1)

生物&药学活性

物理化学性质&存储条件

参考文献

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Pomstafib-1 (Pomstafib 1)

生物&药学活性

物理化学性质&存储条件

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