Pomotrelvir (PBI-0451) | SARS-CoV-2 Mpro inhibitor | Probechem Biochemicals

Chemical Structure : Pomotrelvir

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Pomotrelvir (PBI-0451, PBI 0451)

货号: PC-21248Not For Human Use, Lab Use Only.

Pomotrelvir (PBI-0451) is a potent competitive inhibitor of SARS-CoV-2 Mpro (Ki=2.7 nM) with high selectivity against human proteases, inhibits wild-type SARS-CoV-2 Mpro with IC50 of 24 nM.

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生物&药学活性

Pomotrelvir (PBI-0451) is a potent competitive inhibitor of SARS-CoV-2 Mpro (Ki=2.7 nM) with high selectivity against human proteases, inhibits wild-type SARS-CoV-2 Mpro with IC50 of 24 nM.
Pomotrelvir (PBI-0451) inhibits P132H variant, which is commonly observed in Omicron isolates and has been shown to have no effect on nirmatrelvir inhibition.
Pomotrelvir (PBI-0451) shows broad-spectrum activity against Mpro enzymes from other pathogenic and common cold CoV strains with IC50 ranging from 61 to 379 nM.
Pomotrelvir (PBI-0451) exhibits high selectivity against host proteases.
Pomotrelvir inhibits SARS-CoV-2 with EC50 ofof 32 nM (by plaque assay) and 36 nM (by qRT-PCR) in the SARS CoV-2 assay in iPS-AT2 cells and 23 nM in the SARS-CoV-2 NLuc assay, respectively.

物理化学性质&存储条件

分子量	455.94
分子式	C23H26ClN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-Chloro-N-[(1S)-2-[[(1S)-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]amino]-1-(cyclopropylmethyl)-2-oxoethyl]-1H-indole-2-carboxamide

参考文献

1. Xiao Tong, et al. Antimicrob Agents Chemother. 2023 Oct 6:e0084023.

Pomotrelvir (PBI-0451, PBI 0451)

生物&药学活性

物理化学性质&存储条件

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Pomotrelvir (PBI-0451, PBI 0451)

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物理化学性质&存储条件

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