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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Cyclooxygenase (COX)-Polmacoxib
Polmacoxib

Chemical Structure : Polmacoxib

CAS No.: 301692-76-2

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Polmacoxib (CG-100649, CG100649)

货号: PC-63065Not For Human Use, Lab Use Only.

Polmacoxib (CG-100649) is a novel NSAID proposed to inhibit both COX-2 and carbonic anhydrase (CA)-I/-II.

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10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Polmacoxib (CG-100649) is a novel NSAID proposed to inhibit both COX-2 and carbonic anhydrase (CA)-I/-II.
Polmacoxib inhibits premalignant and malignant colorectal lesions in mouse models, partly through inhibiting tumor cell proliferation.
Polmacoxib induces the G2/M cell cycle arrest in colon cancer cells, and inhibits the tumor growth in colon cancer xenograft in nude mice.

物理化学性质&存储条件

分子量 361.39
分子式 C12H16FNO4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(3-(3-fluorophenyl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)benzenesulfonamide

参考文献

1. Skarke C, et al. Clin Pharmacol Ther. 2012 Jun;91(6):986-93.

2. Kim SH, et al. Invest New Drugs. 2014 Dec;32(6):1105-1112.

3. Woo JK, et al. Oncol Rep. 2015 Apr;33(4):1947-55.

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