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首页-抗体和重组蛋白-Biosimilar Antibody-Polatuzumab
Polatuzumab

Chemical Structure : Polatuzumab

CAS No.: 1313206-42-6

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Polatuzumab (Anti-CD79b mAb, human IgG1-Kappa)

货号: PC-Ab1112Not For Human Use, Lab Use Only.

Polatuzumab (Anti-human CD79b) is a human CD79b mAb, component of antibody-drug conjugate (ADC) Polatuzumab vedotin. Polatuzumab is internalized, cleaved by lysosomal proteases, thereby delivering MMAE to malignant B-cells. The released MMAE binds to microtubules and kills dividing cells by inhibiting cell division and inducing apoptosis. CD79B is a subunit of the heterodimer B-cell receptor Igα/Igβ (CD79A/CD79B), also known as B29, Ig beta and B cell antigen receptor complex-associated protein

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1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Polatuzumab (Anti-human CD79b) is a human CD79b mAb, component of antibody-drug conjugate (ADC) Polatuzumab vedotin. Polatuzumab is internalized, cleaved by lysosomal proteases, thereby delivering MMAE to malignant B-cells. The released MMAE binds to microtubules and kills dividing cells by inhibiting cell division and inducing apoptosis. CD79B is a subunit of the heterodimer B-cell receptor Igα/Igβ (CD79A/CD79B), also known as B29, Ig beta and B cell antigen receptor complex-associated protein beta-chain.

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Polatuzumab; Anti-human CD79b; Anti-human B-cell receptor Igβ; 1313206-42-6

参考文献

1. 1, Sehn LH, et al. J Clin Oncol. 2020 Jan 10;38(2):155-165. 2, Bourbon E, et al. Expert Opin Investig Drugs. 2020 Oct;29(10):1079-1088. 3, Tilly H, et al. Lancet Oncol. 2019 Jul;20(7):998-1010. 4, Segman Y, et al. Leuk Lymphoma. 2021 Jan;62(1):118-124.

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