Pocapavir (V-073, SCH48973)

Chemical Structure : Pocapavir

CAS No.: 146949-21-5

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货号: PC-20018Not For Human Use, Lab Use Only.

Pocapavir (V-073, SCH48973) is a potent, selective, antienterovirus inhibitor with IC50 of 0.02 to 0.11 ug/mL, specifically interacts with viral capsid.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

Pocapavir (V-073, SCH48973) is a potent, selective, antienterovirus inhibitor with IC50 of 0.02 to 0.11 ug/mL, specifically interacts with viral capsid.
Pocapavir (V-073, SCH48973) shows high affinity for binding to poliovirus capsid with Ki of 0.9 nM.
Pocapavir (V-073, SCH48973) demonstrated efficacy in a murine poliovirus model of enterovirus disease.
Pocapavir (V-073, SCH48973) increased the survival of infected mice when it was administered orally at dosages of 3 to 20 mg/kg of body weight/day.
Oral administration of Pocapavir (V-073, SCH48973) also reduced viral titers in the brains of infected mice.

物理化学性质&存储条件

分子量	423.71
分子式	C21H17Cl3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,3-dichloro-2-((4-((2-chloro-4-methoxyphenoxy)methyl)benzyl)oxy)benzene

参考文献

1. Buontempo PJ, et al. Antimicrob Agents Chemother. 1997 Jun;41(6):1220-5.

2. Lentz KN, et al. Structure. 1997 Jul 15;5(7):961-78.

3. Liu HM, et al. Antimicrob Agents Chemother. 2012 Nov;56(11):5568-74.