Plumbagin | TRPV2 inhibitor | Probechem Biochemicals

Chemical Structure : Plumbagin

CAS No.: 481-42-5

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Plumbagin (2-Methyljuglone)

货号: PC-23230Not For Human Use, Lab Use Only.

规格	价格	库存
50 mg	￥880	In stock
100 mg	￥1280	In stock
500 mg	￥2880	In stock
1 g		Get quote

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生物&药学活性

Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica, exhibits anticancer and antiproliferative activities, also is a potent TRPV2 negative allosteric modulator with IC50 of 0.85 μM, exhibiting >14-fold selectivity over TRPV1, TRPV3 and TRPV4.
Plumbagin (2-Methyljuglone) also is a novel PKM2 inhibitor and it could bind to PKM2 to inhibit the enzymatic activity, induces oxidative stress and apoptosis in hepatoma cells.
Plumbagin (2-Methyljuglone) also inhibits the cytosolic glutathione-degrading enzyme, ChaC1 with IC50 of 8.7 uM.
Plumbagin inhibits fungal growth, HMGB1/LOX-1 pathway and inflammatory factors in A. fumigatus keratitis.

物理化学性质&存储条件

分子量	188.18
分子式	C11H8O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Hydroxy-2-methylnaphthalene-1,4-dione

参考文献

1. Wu J, et al. RSC Med Chem. 2024 Sep 20. doi: 10.1039/d4md00519h.

2. Suyal S, et al. Biochem J. 2024 Oct 16;481(20):1475-1495.

3. Ding M, et al. Br J Pharmacol. 2024 Oct 3. doi: 10.1111/bph.17343.

Plumbagin (2-Methyljuglone)

生物&药学活性

物理化学性质&存储条件

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Plumbagin (2-Methyljuglone)

生物&药学活性

物理化学性质&存储条件

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