Plocabulin | Tubulin inhibitor | Probechem Biochemicals

Chemical Structure : Plocabulin

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Plocabulin (PM060184, PM-060184)

货号: PC-35334Not For Human Use, Lab Use Only.

Plocabulin (PM060184) is a novel tubulin-binding agent binding to αβ-tubulin dimer with nanomolar affinity, inhibits a panel of 23 tumor cell lines with GI50 of 20 pM-5 nM.

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生物&药学活性

Plocabulin (PM060184) is a novel tubulin-binding agent binding to αβ-tubulin dimer with nanomolar affinity, inhibits a panel of 23 tumor cell lines with GI50 of 20 pM-5 nM.
Plocabulin inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells.
Plocabulin also shows antifungal activity virtually abolishing growth of the filamentous fungus Aspergillus nidulans.

物理化学性质&存储条件

分子量	571.715
分子式	C31H45N3O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	[(1Z,4S,6Z)-1-[[(2S)-2-[[(2Z,4Z,6E,8S)-8-[(2S)-5-methoxy-6-oxo-2,3-dihydropyran-2-yl]-6-methylnona-2,4,6-trienoyl]amino]-3,3-dimethylbutanoyl]amino]octa-1,6-dien-4-yl] carbamate

参考文献

1. Galmarini CM, et al. BMC Cancer. 2018 Feb 7;18(1):164.

2. Pantazopoulou A, et al. Sci Rep. 2018 Jun 5;8(1):8616.

3. Pera B, et al. ACS Chem Biol. 2013 Sep 20;8(9):2084-94.

4. Prota AE, et al. Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13817-21.

Plocabulin (PM060184, PM-060184)

生物&药学活性

物理化学性质&存储条件

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Plocabulin (PM060184, PM-060184)

生物&药学活性

物理化学性质&存储条件

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