Plitidepsin | eEF1A inhibitor | Probechem Biochemicals

Chemical Structure : Plitidepsin

CAS No.: 137219-37-5

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Plitidepsin (Aplidine, PM90001, N-[1-(1,2-dioxopropyl)-L-prolyl]-didemnin A)

货号: PC-21728Not For Human Use, Lab Use Only.

Plitidepsin (Aplidine) is a potent anti-cancer agent by targeting eEF1A2 with KD value of 80 nM, shows antiviral activity against SARS-CoV-2 with IC90 of 0.88 nM.

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5 mg	￥5280	In stock
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生物&药学活性

Plitidepsin (Aplidine) is a potent anti-cancer agent by targeting eEF1A2 with KD value of 80 nM, shows antiviral activity against SARS-CoV-2 with IC90 of 0.88 nM.

物理化学性质&存储条件

分子量	1110.36
分子式	C57H87N7O15
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-((R)-1-(((3S,6R,7S,10R,11S,15S,17S,20S,25aS)-10-((S)-sec-butyl)-11-hydroxy-20-isobutyl-15-isopropyl-3-(4-methoxybenzyl)-2,6,17-trimethyl-1,4,8,13,16,18,21-heptaoxodocosahydro-15H-pyrrolo[2,1-f][1,15]dioxa[4,7,10,20]tetraazacyclotricosin-7-yl)amino)-4-methyl-1-oxopentan-2-yl)-N-methyl-1-(2-oxopropanoyl)pyrrolidine-2-carboxamide

参考文献

1. Alejandro Losada, et al. Sci Rep. 2016 Oct 7;6:35100.

2. Kris M White, et al. Science. 2021 Feb 26;371(6532):926-931.

Plitidepsin (Aplidine, PM90001, N-[1-(1,2-dioxopropyl)-L-prolyl]-didemnin A)

生物&药学活性

物理化学性质&存储条件

参考文献

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Plitidepsin (Aplidine, PM90001, N-[1-(1,2-dioxopropyl)-L-prolyl]-didemnin A)

生物&药学活性

物理化学性质&存储条件

参考文献

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