欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Microtubule/Tubulin-Plinabulin
Plinabulin

Chemical Structure : Plinabulin

CAS No.: 714272-27-2

加入收藏

Plinabulin (NPI-2358, NPI 2358)

货号: PC-21390Not For Human Use, Lab Use Only.

Plinabulin (NPI-2358) is a small molecule vascular disrupting agent against tubulin-depolymerizing, shows IC50 of 9.8 nM against HT-29 cells.

规格 价格 库存 数量
10 mg ￥1880 In stock
25 mg ￥2980 In stock
50 mg ￥4580 In stock
100 mg Get quote
1 g Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Plinabulin (NPI-2358) is a small molecule vascular disrupting agent against tubulin-depolymerizing, shows IC50 of 9.8 nM against HT-29 cells.
Plinabulin (NPI-2358) exhibits potent interruption of tumor blood flow because of the disruption of tumor vascular endothelial cells, resulting in tumor necrosis.
Plinabulin (NPI-2358) elicits tumor vascular endothelial architectural destabilization leading to selective collapse of established tumor vasculature.
Plinabulin (NPI-2358) also induces apoptotic cell death in MM cell lines and tumor cells from patients with MM, associated with mitotic growth arrest.
Plinabulin (NPI-2358) triggers JNK-mediated apoptosis and inhibits angiogenesis in multiple myeloma cells.

物理化学性质&存储条件

分子量 336.39
分子式 C19H20N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-3-((Z)-benzylidene)-6-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)piperazine-2,5-dione

参考文献

1. Yamazaki Y, et al. J Med Chem. 2012 Feb 9;55(3):1056-71.

2. Singh AV, et al. Blood. 2011 May 26;117(21):5692-700.

3. Nicholson B, et al. Anticancer Drugs. 2006 Jan;17(1):25-31.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: