Plevitrexed (ZD 9331, BGC 9331) | Antifolate | Probechem Biochemicals

Chemical Structure : Plevitrexed

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Plevitrexed (BGC 9331, ZD9331)

货号: PC-49047Not For Human Use, Lab Use Only.

Plevitrexed (ZD 9331, BGC 9331) is a reduced-folate carrier system (RFC)-mediated thymidylate synthase inhibitor with Ki of 0.44 nM.

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生物&药学活性

Plevitrexed (ZD 9331, BGC 9331) is a reduced-folate carrier system (RFC)-mediated thymidylate synthase inhibitor with Ki of 0.44 nM.
Plevitrexed selectively binds to the folate binding site of thymidylate synthase and inhibits thymidine synthesis, causes DNA synthesis inhibition and apoptosis.

物理化学性质&存储条件

分子量	532.53
分子式	C26H25FN8O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(4-(((2,7-dimethyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl)(prop-2-yn-1-yl)amino)-2-fluorobenzamido)-4-(1H-tetrazol-5-yl)butanoic acid

参考文献

1. Jackman AL, et al. Clin Cancer Res. 1997 Jun;3(6):911-21.

2. Jackman AL, et al. Adv Exp Med Biol. 1994;370:185-8.

Plevitrexed (BGC 9331, ZD9331)

生物&药学活性

物理化学性质&存储条件

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Plevitrexed (BGC 9331, ZD9331)

生物&药学活性

物理化学性质&存储条件

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