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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Topoisomerase-Pixantrone
Pixantrone

Chemical Structure : Pixantrone

CAS No.: 144675-97-8

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Pixantrone (BBR2778)

货号: PC-22736Not For Human Use, Lab Use Only.

Pixantrone (BBR2778) dimaleate is a topoisomerase II inhibitor and DNA intercalator with anti-tumor activity, also is a direct mini-chromosome maintenance protein 2 (MCM2) inhibitor, induces cell cycle arrest and apoptosis in ovarian cancer cells via targeting MCM2.

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25 mg ￥1380 In stock
50 mg ￥2280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Pixantrone (BBR2778) dimaleate is a topoisomerase II inhibitor and DNA intercalator with anti-tumor activity, also is a direct mini-chromosome maintenance protein 2 (MCM2) inhibitor, induces cell cycle arrest and apoptosis in ovarian cancer cells via targeting MCM2.

物理化学性质&存储条件

分子量 557.52
分子式 C25H27N5O10
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6,9-Bis((2-aminoethyl)amino)benzo[g]isoquinoline-5,10-dione dimaleate

参考文献

1. Chen Q, et al. Eur J Pharmacol. 2024 Jul 18:176835.et al.

2. Beeharry N, et al. Cancer Biol Ther. 2015;16(9):1397-406.

3. Hasinoff BB, et al. J Pharmacol Exp Ther. 2016 Feb;356(2):397-409.

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