Pitstop 2d

Chemical Structure : Pitstop 2d

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货号: PC-24288Not For Human Use, Lab Use Only.

Pitstops 2d is a next-generation small molecule inhibitors of clathrin function (IC50=13 uM, inhibition of transferrin), inhibits crlathrin-mediated endocytosis.

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生物&药学活性

Pitstops 2d is a next-generation small molecule inhibitors of clathrin function (IC50=13 uM, inhibition of transferrin), inhibits crlathrin-mediated endocytosis.
Pitstops 2d does not affect the nuclear permeability barrier and exhibits low cytotoxicity.
Pitstops 2d displaces amphiphysin from the clathrin TD in vitro with IC50 of 1.7 uM.
Pitstops 2d inhibits VSV entry into Vero-E6 cells.
Pitstops 2d does not impair clathrin-independent endocytosis of dextran.
Pitstops 2d inhibits early stages of CME by displacing epsins from clathrin.

物理化学性质&存储条件

分子量	486.56
分子式	C26H18N2O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-N-(4-oxo-5-(2-phenoxybenzylidene)-4,5-dihydrothiazol-2-yl)naphthalene-2-sulfonamide

参考文献

1. Horatscheck A, et al. Structure. 2025 Mar 7:S0969-2126(25)00064-4.

Pitstop 2d

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Pitstop 2d

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