Pitstop 2c

Chemical Structure : Pitstop 2c

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货号: PC-24287Not For Human Use, Lab Use Only.

Pitstops 2c is a next-generation small molecule inhibitors of clathrin function (IC50=13 uM, inhibition of transferrin), inhibits crlathrin-mediated endocytosis.

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生物&药学活性

Pitstops 2c is a next-generation small molecule inhibitors of clathrin function (IC50=13 uM, inhibition of transferrin), inhibits crlathrin-mediated endocytosis.
Pitstops 2c does not affect the nuclear permeability barrier and exhibits low cytotoxicity.
Pitstops 2c displaces amphiphysin from the clathrin TD in vitro with IC50 of 1.8 uM.
Pitstops 2c inhibits VSV entry into Vero-E6 cells.
Pitstops 2c does not impair clathrin-independent endocytosis of dextran.
Pitstops 2c inhibits early stages of CME by displacing epsins from clathrin.

物理化学性质&存储条件

分子量	486.56
分子式	C26H18N2O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-N-(4-oxo-5-(2-phenoxybenzylidene)-4,5-dihydrothiazol-2-yl)naphthalene-1-sulfonamide

参考文献

1. Horatscheck A, et al. Structure. 2025 Mar 7:S0969-2126(25)00064-4.

Pitstop 2c

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Pitstop 2c

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