Pitstop 2 |CAS:1419093-54-1 Probechem Biochemicals

Chemical Structure : Pitstop 2

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Pitstop 2 (Pitstop-2;Pitstop2)

货号: PC-60190Not For Human Use, Lab Use Only.

Pitstop 2 is a small molecule inhibitor of clathrin terminal domain and inhibits clathrin-mediated endocytosis.

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生物&药学活性

Pitstop 2 is a small molecule inhibitor of clathrin terminal domain and inhibits clathrin-mediated endocytosis.
Pitstop 2 inhibits endocytosis of transferrin receptor, a CDE cargo protein, but not affect endocytosis of shiga toxin.
Pitstop 2 traps HeLa cells in metaphase through loss of mitotic spindle integrity and activation of the spindle assembly checkpoint.
Pitstop 2 is a useful tool for investigating clathrin spindle dynamics.

物理化学性质&存储条件

分子量	473.36
分子式	C20H13BrN2O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-N-(5-(4-bromobenzylidene)-4-oxo-4,5-dihydrothiazol-2-yl)naphthalene-1-sulfonamide

参考文献

1. Dutta D, et al. PLoS One. 2012;7(9):e45799.

2. Smith CM, et al. Mol Cancer. 2013 Jan 17;12:4.

3. Liashkovich I, et al. Sci Rep. 2015 May 6;5:9994.

4. Willox AK, et al. Biol Open. 2014 Apr 4;3(5):326-31.

Pitstop 2 (Pitstop-2;Pitstop2)

生物&药学活性

物理化学性质&存储条件

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Pitstop 2 (Pitstop-2;Pitstop2)

生物&药学活性

物理化学性质&存储条件

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