Pirtobrutinib (LOXO-305) | BTK inhibitor | Probechem Biochemicals

Chemical Structure : Pirtobrutinib

CAS No.: 2101700-15-4

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Pirtobrutinib (LOXO-305, LOXO305, LY3527727, RXC-005)

货号: PC-72630Not For Human Use, Lab Use Only.

Pirtobrutinib (LOXO-305, LY3527727, RXC-005) is a highly potent and selective non-covalent BTK inhibitor with IC50 of 5.69 nM, shows nanomolar potency against both wild-type and C481-mutated BTK.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

Pirtobrutinib (LOXO-305, LY3527727, RXC-005) is a highly potent and selective non-covalent BTK inhibitor with IC50 of 5.69 nM.
LOXO-305 shows nanomolar potency against both wild-type and C481-mutated BTK.
LOXO-305 displays >300 fold selectivity on BTK over 98% of other kinases, reducing the potential for off-target toxicities.
Pirtobrutinib (LOXO-305) has been designed to maintain greater than 90% of maximal BTK inhibition at trough, thereby achieving effective target inhibition throughout the dosing interval, even in proliferative tumours.

物理化学性质&存储条件

分子量	479.436
分子式	C22H21F4N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-amino-3-[4-[[(5-fluoro-2-methoxybenzoyl)amino]methyl]phenyl]-1-[(2S)-1,1,1-trifluoropropan-2-yl]pyrazole-4-carboxamide

参考文献

1. Brandhuber B, et al. Clin. Lymphoma Myeloma Leuk. 2018;18:S216.

2. Ito K, et al. Eur J Cancer. 2021 Mar;145:183-193.

Pirtobrutinib (LOXO-305, LOXO305, LY3527727, RXC-005)

生物&药学活性

物理化学性质&存储条件

参考文献

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Pirtobrutinib (LOXO-305, LOXO305, LY3527727, RXC-005)

生物&药学活性

物理化学性质&存储条件

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