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首页-小分子抑制剂&激动剂-GPCR-Melatonin Receptor-Piromelatine
Piromelatine

Chemical Structure : Piromelatine

CAS No.: 946846-83-9

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Piromelatine (Neu-P11)

货号: PC-61335Not For Human Use, Lab Use Only.

Piromelatine (Neu-P11) is a melatonin melatonin receptor MT1/MT2 and serotonin 5-HT1A/5-HT1D receptor agonist.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Piromelatine (Neu-P11) is a melatonin melatonin receptor MT1/MT2 and serotonin 5-HT1A/5-HT1D receptor agonist.
Piromelatine inhibits weight gain and improves insulin sensitivity in high-fat/high-sucrose-fed rats。
Piromelatine facilitates memory performance and improves cognitive impairment in a rat model of Alzheimer' disease.

物理化学性质&存储条件

分子量 312.32
分子式 C17H16N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]-4-oxo-4H-pyran-2-carboxamide

参考文献

1. She M, et al. Eur J Pharmacol. 2014 Mar 15;727:60-5.

2. Liu YY, et al. Psychopharmacology (Berl). 2014 Oct;231(20):3973-85.

3. She M, et al. Pharmacol Res. 2009 Apr;59(4):248-53.

4. Zhou J, et al. J Pharmacol Exp Ther. 2018 Jan;364(1):55-69.

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