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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Nucleoside Antimetabolite/Analog-Piritrexim
Piritrexim

Chemical Structure : Piritrexim

CAS No.: 72732-56-0

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Piritrexim (BW 301U, NSC 351521)

货号: PC-26914Not For Human Use, Lab Use Only.

Piritrexim (BW301U) is a lipophilic antifolate and potent dihydrofolate reductase (DHFR) inhibitor against Pneumocystis carinii and Toxoplasma gondii, with IC50 of 0.038 and 0.011 uM, respectively, shows antiparasitic, antipsoriatic and antitumor properties.

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5 mg ￥4980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Piritrexim (BW301U) is a lipophilic antifolate and potent dihydrofolate reductase (DHFR) inhibitor against Pneumocystis carinii and Toxoplasma gondii, with IC50 of 0.038 and 0.011 uM, respectively, shows antiparasitic, antipsoriatic and antitumor properties.

物理化学性质&存储条件

分子量 325.37
分子式 C17H19N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(2,5-Dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine

参考文献

1. Rosowsky A, et al. J Med Chem. 1993 Oct 15;36(21):3103-12.

2. Sedwick WD, et al. Mol Pharmacol. 1982 Nov;22(3):766-70.

3. Grivsky EM, et al. J Med Chem. 1980 Mar;23(3):327-9. doi: 10.1021/jm00177a025.

4. de Vries EG, et al. Br J Cancer. 1993 Sep;68(3):641-4.

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