Pirepemat (IRL752)

Chemical Structure : Pirepemat

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货号: PC-38369Not For Human Use, Lab Use Only.

Pirepemat (IRL752) is a new phenyl-pyrrolidine derivative and cognition-promoting agent with regioselective central nervous system transmission-enhancing properties, enhances norepinephrine, dopamine, and acetylcholine neurotransmission in the cerebral cortex.

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生物&药学活性

Pirepemat (IRL752) is a new phenyl-pyrrolidine derivative and cognition-promoting agent with regioselective central nervous system transmission-enhancing properties, enhances norepinephrine, dopamine, and acetylcholine neurotransmission in the cerebral cortex.
Pirepemat (IRL752) normalized tetrabenazine-induced hypoactivity, whereas it was unable to stimulate basal locomotion in normal animals or either accentuate or reverse hyperactivity induced by amphetamine or MK-801.
IRL752 induced but minor changes in monoaminergic tissue neurochemistry across noradrenaline (NA)- and dopamine (DA)-dominated brain regions.

物理化学性质&存储条件

分子量	213.228
分子式	C11H13F2NO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine

参考文献

1. Svenningsson P, et al. Mov Disord. 2020 Jun;35(6):1046-1054.

2. Hjorth S, et al. J Pharmacol Exp Ther. 2020 Sep;374(3):404-419.