Piragliatin (RO 4389620, R-1440)

Chemical Structure : Piragliatin

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货号: PC-61875Not For Human Use, Lab Use Only.

Piragliatin (RO 4389620, R-1440) is an allosteric, potent Glucokinase (GK) activator with SC1.5 of 0.18 uM.

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生物&药学活性

Piragliatin (RO 4389620, R-1440) is an allosteric, potent Glucokinase (GK) activator with SC1.5 of 0.18 uM.
Piragliatin lowers pre- and postprandial glucose levels, improves the insulin secretory profile, increases β-cell sensitivity to glucose, and decreases hepatic glucose in vivo.

物理化学性质&存储条件

分子量	421.896
分子式	C19H20ClN3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R)-2-(3-Chloro-4-(methylsulfonyl)phenyl)-3-((1R)-3-oxocyclopentyl)-N-pyrazinylpropanamide

参考文献

1. Sarabu R, et al. J Med Chem. 2012 Aug 23;55(16):7021-36.

2. Bonadonna RC, et al. J Clin Endocrinol Metab. 2010 Nov;95(11):5028-36.

3. Zhi J, et al. J Clin Pharmacol. 2016 Feb;56(2):231-8.

4. Kim MK, et al. PLoS One. 2013 Sep 19;8(9):e73340.