Pipersentan | ETA receptor antagonist | Probechem Biochemicals

Chemical Structure : Pipersentan

加入收藏

Pipersentan (Diosuxentan)

货号: PC-25043Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Pipersentan (Diosuxentan) is a potent, selective endothelin receptor A (ETA receptor) antagonist, inhibits binding of 125I-ET-1 toward recombinant ETA receptor with IC50 of 4.44 nM, >1000-fold selective over ETB receptor.
Pipersentan completely inhibits the high intracellular calcium induced by ET-1 in recombinant CHO and SK-N-MC cells with IC50 of 1.6 nM, >30,000-fold selective over ET B.
Pipersentan efficaciously antagonized the effects of ET-1 on pulmonary artery smooth muscle cell proliferation, migration and calcium mobilization and effectively improved right ventricular hypertrophy and pulmonary arterial pressure in both monocrotaline- and hypoxia-induced pulmonary hypertension (PH) rat models.

物理化学性质&存储条件

分子量	569.39
分子式	C20H21BrN6O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Sulfamide, N-[5-(1,3-benzodioxol-5-yl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N′-(2-methoxyethyl)-

参考文献

1. Zeyu Zhang, et al. Front Pharmacol. 2022 Jun 20:13:920222.

Pipersentan (Diosuxentan)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Pipersentan (Diosuxentan)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.