Pin1 inhibitor H-77

Chemical Structure : Pin1 inhibitor H-77

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货号: PC-73344Not For Human Use, Lab Use Only.

Pin1 inhibitor H-77 (H-77) is a small molecule Pin1 inhibitor that blocks SARS-CoV-2 proliferation with EC50 of 3.2 uM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

Pin1 inhibitor H-77 (H-77) is a small molecule Pin1 inhibitor that blocks SARS-CoV-2 proliferation with EC50 of 3.2 uM.
H-77 exhibited strong inhibitory effects on SARS-CoV-2 proliferation regardless of whether it was added to the culture medium prior to or after SARS-CoV-2 infection, measured by both viral mRNA and protein synthesis, and alleviated the cytopathic effect (CPE) on VeroE6/TMPRSS2 cells.
Pin1 inhibitors could serve as potential therapeutic agents for COVID-19.

物理化学性质&存储条件

分子量	397.430
分子式	C25H19NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-naphthamido)-5-(benzyloxy)benzoic acid

参考文献

1. Takeshi Yamamotoya, et al. Sci Rep. 2021 Sep 17;11(1):18581.