Pimozide | STAT5 inhibitor, USP1 inhibitor | Probechem Biochemicals

Chemical Structure : Pimozide

CAS No.: 2062-78-4

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Pimozide (R6238)

货号: PC-62444Not For Human Use, Lab Use Only.

Pimozide (R6238) is an antipsychotic agent that acts as an antagonist of the D2, D3, and D4 receptors and the 5-HT7 receptor, also is an inhbitor of STAT5.

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100 mg	￥1480	In stock
500 mg	￥2880	In stock
1 g	￥3980	In stock
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生物&药学活性

Pimozide (R6238) is an antipsychotic agent that acts as an antagonist of the D2, D3, and D4 receptors and the 5-HT7 receptor, also is an inhbitor of STAT5.
Pimozide also is a hERG blocker, inhibits USP1/UAF1 noncompetitively with Ki of 0.5 uM.
Pimozide displays selectivity against a number of deubiquitinases, deSUMOylase, and cysteine proteases.

物理化学性质&存储条件

分子量	461.56
分子式	C28H29F2N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one

参考文献

1. Chen J, et al. Chem Biol. 2011 Nov 23;18(11):1390-400.

2. Nelson EA, et al. Blood. 2011 Mar 24;117(12):3421-9.

3. Rondanin R, et al. ChemMedChem. 2017 Aug 8;12(15):1183-1190.

Pimozide (R6238)

生物&药学活性

物理化学性质&存储条件

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Pimozide (R6238)

生物&药学活性

物理化学性质&存储条件

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