Pim-IN-22m |CAS:1405126-60-4 Probechem Biochemicals

首页-小分子抑制剂&激动剂-JAK/STAT Signaling-Pim-Pim-IN-22m

Chemical Structure : Pim-IN-22m

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Pim-IN-22m

货号: PC-62787Not For Human Use, Lab Use Only.

Pim-IN-22m is a potent, selective Pim1/Pim2 inhibitor with IC50 of 24/95 pM respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Pim-IN-22m is a potent, selective Pim1/Pim2 inhibitor with IC50 of 24/95 pM respectively.
Pim-IN-22mpotently inhibits the phosphorylation of BAD (s112) in a cell line that expresses high levels of all Pim isoforms, KMS-12-BM (IC50=28 nM).

物理化学性质&存储条件

分子量	435.483
分子式	C23H23F2N7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((3S,5R)-3-amino-5-methylpiperidin-1-yl)pyridin-3-yl)-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amine

参考文献

1. Wurz RP, et al. Bioorg Med Chem Lett. 2016 Nov 15;26(22):5580-5590.

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Pim-IN-22m

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物理化学性质&存储条件

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Pim-IN-22m

生物&药学活性

物理化学性质&存储条件

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