Pifithrin-μ | p53 inhibitor | Probechem Biochemicals

Chemical Structure : Pifithrin-μ

CAS No.: 64984-31-2

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Pifithrin-μ (PFTμ, 2-Phenylethynesulfonamide)

货号: PC-24085Not For Human Use, Lab Use Only.

Pifithrin-μ is a specific small molecule inhibitor of p53 and HSP70, shows antitumor and neuroprotective activity.

规格	价格	库存
5 mg	￥450	In stock
10 mg	￥680	In stock
50 mg	￥1580	In stock
100 mg		Get quote

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生物&药学活性

Pifithrin-μ is a specific small molecule inhibitor of p53 and HSP70, shows antitumor and neuroprotective activity.
inhibits p53 binding to mitochondria by reducing its affinity to antiapoptotic proteins Bcl-xL and Bcl-2 but has no effect on p53-dependent transactivation, activity of caspases 2, 8, 9 and 10 in a cell-free system, or NF-κB-dependent transcription.
reduces viability in A549 cells, with IC50s of 44.9 and 25.7 µM at 24 h and 48 h.
Pifithrin-μ (20 μM) suppresses the cell migration, induces cell cycle arrest and cell apoptosis in A549 and H460 cells.
Pifithrin-μ (10 uM, 20 µM) inhibits activities of AKT, ERK, and Hsp70 in A549 and H460 cells.
Pifithrin-μ (20 µM) sensitizes A549 and H460 cell lines to TRAIL-induced cell proliferation inhibition and apoptosis.

物理化学性质&存储条件

分子量	181.21
分子式	C8H7NO2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Phenylethyne-1-sulfonamide

参考文献

1. Strom E, et al. Nat Chem Biol. 2006 Sep;2(9):474-9. Epub 2006 Jul 23.

2. Zhou Y, et al. Oncol Rep. 2017 Jan;37(1):313-322.

Pifithrin-μ (PFTμ, 2-Phenylethynesulfonamide)

生物&药学活性

物理化学性质&存储条件

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Pifithrin-μ (PFTμ, 2-Phenylethynesulfonamide)

生物&药学活性

物理化学性质&存储条件

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