Pibrentasvir | HCV NS5A inhibitor | Probechem Biochemicals

Chemical Structure : Pibrentasvir

CAS No.: 1353900-92-1

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Pibrentasvir (ABT-530, ABT530)

货号: PC-63073Not For Human Use, Lab Use Only.

Pibrentasvir (ABT-530) is a novel and pan-genotypic HCV NS5A inhibitor with EC50 of 1.4-5.0 pM against HCV replicons containing NS5A genotypes 1-6.

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50 mg	￥1380	In stock
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生物&药学活性

Pibrentasvir (ABT-530) is a novel and pan-genotypic HCV NS5A inhibitor with EC50 of 1.4-5.0 pM against HCV replicons containing NS5A genotypes 1-6.
Pibrentasvir demonstrates potent antiviral activity and acceptable safety during 3-day monotherapy in patients with HCV genotype 1 infection, with or without compensated cirrhosis.

物理化学性质&存储条件

分子量	1113.2
分子式	C57H65F5N10O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Dimethyl ((2S,2'S,3R,3'R)-((2S,2'S)-(((2R,5R)-1-(3,5-difluoro-4-(4-(4-fluorophenyl)piperidin-1-yl)phenyl)pyrrolidine-2,5-diyl)bis(6-fluoro-1H-benzo[d]imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methoxy-1-oxobutane-1,2-diyl))dicarbamate

参考文献

1. Lawitz EJ, et al. Antimicrob Agents Chemother. 2015 Dec 28;60(3):1546-55.

2. Poordad F, et al. Liver Int. 2016 Aug;36(8):1125-32.

3. Ng TI, et al. Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02558-16.

Pibrentasvir (ABT-530, ABT530)

生物&药学活性

物理化学性质&存储条件

参考文献

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Pibrentasvir (ABT-530, ABT530)

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